Early Differentiation of Glucagon-Producing Cells in Embryonic Pancreas: A Possible Developmental Role for Glucagon
نویسندگان
چکیده
منابع مشابه
Early differentiation of glucagon-producing cells in embryonic pancreas: a possible developmental role for glucagon.
Glucagon and insulin are first detectable at the onset of rat pancreas organogenesis. Initially, the specific activity of glucagon is approximately 100-fold higher than that of insulin. At this early stage, endocrine storage granules, similar to alpha granules, are identifiable in electron micrographs. The granule characteristics, as well as the relative hormone levels, suggest that the early p...
متن کاملGlucagon is required for early insulin-positive differentiation in the developing mouse pancreas.
The embryonic pancreas is thought to develop from pluripotent endodermal cells that give rise to endocrine and exocrine cells. A key guidance mechanism for pancreatic development has previously been found to be epithelial-mesenchymal interaction. Interactions within the epithelium, however, have not been well studied. Glucagon is the earliest peptide hormone present at appreciable levels in the...
متن کاملGlucagon in Perfused Rat Pancreas
The biosynthesis of glucagon was studied by using the recirculated, isolated perfused rat pancreas. [3H]Tryptophan was initially incorporated into acid-ethanol-extractable protein, which on gel filtration was eluted with a molecular weight ofabout 9000 and contained a small amount of glucagon immunoreactivity. With longer incubation [3H]tryptophan incorporation into a second peak was obtained i...
متن کاملRelation of glucagon to A cells of the pancreas.
In spite of the amount of work done on origin of glucagon, there is no agreement as to the site of its production (1-5). Some investigators found a significant reduction of glucagon in the pancreas of cobalt-treated guinea pigs and dogs(8,9); others found no diminution in glucagon content of cobalt-treated dogs(6,7); while others stated that the glucagon content of cobalt-treated rabbits was tw...
متن کاملEffect of selegiline on neural stem cells differentiation: a possible role for neurotrophic factors
Objective(s): The stimulation of neural stem cells (NSCs) differentiation into neurons has attracted great attention in management of neurodegenerative disease and traumatic brain injury. It has been reported that selegiline could enhance the morphologic differentiation of embryonic stem cells. Therefore this study aimed to investigate the effects of selegiline on NSCs differentiation with focu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1973
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.70.12.3478